ViGeneron Announces First Patient Dosed in Phase 1b Trial of VG901 for the Intravitreal Treatment of RP
ViGeneron announced that the first patient has been dosed in its phase Ib clinical trial evaluating intravitreal injection of VG901 to treat retinitis pigmentosa (RP) caused by mutations in the CNGA1 gene. This milestone marks an important advance as the company continues to leverage its next-generation technology platforms to develop gene therapies addressing critical unmet medical needs.
“By delivering a functional CNGA1 gene to retinal photoreceptor target cells, VG901 offers a therapeutic potential in addressing the genetic root cause for patients with retinitis pigmentosa affected by CNGA1 mutations,” Prof. Dr. Katarina Stingl, Head of the Clinic for Hereditary Retinal Degenerations in the Center for Ophthalmology and the Center for Rare Eye Diseases at the University of Tübingen, Germany, and the Principal Investigator for this trial, said in a company news release. "We are excited to learn about the potential of this novel therapy and hope to make a meaningful difference to patients' lives.”
“Dosing our first patient in the VG901 phase Ib clinical trial is a significant step forward for the company and for the patients we aim to benefit. VG901 has also been granted FDA Orphan Drug Designation status. We look forward to progressing the clinical development of this potentially transformative therapy,” said Dr. Caroline Man Xu, ViGeneron’s Co-founder and CEO. “Not only is the phase 1b trial designed to provide key insights into the safety and preliminary efficacy of VG901, it is also a pivotal step in validating our next generation vector platform vgAAV, which has demonstrated superior transduction efficiency and enables intravitreal delivery.”
The ongoing phase 1b clinical trial is an open-label, single-arm, dose-escalation study investigating the safety, tolerability, and preliminary efficacy of an intravitreal injection of VG901, a first-in-class CNGA1 gene therapy for autosomal recessive RP. For more information on the trial, visit clinicaltrial.gov [NCT06291935].