Reduction of Eyedrop Volume for Topical Ophthalmic Medications with the Nanodropper Bottle Adaptor
Nanodropper announced positive results from a research study conducted in collaboration with Leonard Seibold, MD, Professor of Ophthalmology at University of Colorado School of Medicine, which quantified eyedrop volume reduction and bottle life extension with the Nanodropper adaptor compared to standard eyedrops.
The study, titled “Reduction of Eyedrop Volume for Topical Ophthalmic Medications with the Nanodropper Bottle Adaptor," was published in the journal Medical Devices: Evidence and Research. The study found that eye drops administered with the adaptor are, on average, more than 62 percent smaller than typical drops.
“We know based on decades of research on microvolume delivery of eye drops that conventional drops are too large for the eye to absorb, and that drops as small as five microliters are as efficacious as their larger counterparts,” Jennifer Steger, PhD, Chief Scientific Officer for Nanodropper, said in a company news release.
The study was designed to determine the drop volume and total number of dispensed drops using the Nanodropper Adaptor, compared to drops dispensed from stock bottles “to potentially limit ocular toxicity of these eyedrops and prolong bottle use.”
According to the study, the drops delivered with the Nanodropper Adaptor were 62.1% smaller than eyedrops administered from standard bottles. This equated to 2.6-fold increase in the number of drops in a 2.5 milliliter bottle (on average, 184.1 drops with Nanodropper vs. 69.8 drops from a stock bottle).
“The Nanodropper bottle adaptor significantly reduces the eye drop volume dispensed each time compared to the drops dispensed from a stock bottle, and is similarly effective across multiple medication types and bottle sizes including solutions, suspensions, or emulsions from different manufacturers,” says Dr. Seibold, who also serves as the Director of Glaucoma Fellowship at the Sue Anschultz-Rodgers Eye Center. “The ability to deliver a smaller eyedrop may help to reduce medication waste, prolong the useful life of each medication bottle, reduce cost, and as a result, may positively impact patient adherence to prescribed eyedrop therapies."