Oyster Point Pharma to Present New Scientific Analyses at World Cornea Congress VIII
Oyster Point Pharma announced it will present new scientific analyses at World Cornea Congress VIII, which is taking place in Chicago from September 28-29, 2022.
“We look forward to presenting our post-hoc analyses on the clinical benefits of Tyrvaya (varenicline solution) nasal spray as well as the results of evaluating inflammatory cytokine levels in tears in healthy and dry eye disease patients at this year’s World Cornea Congress, an event that highlights the progress that has been made in both clinical and research endeavors of the international cornea community,” said Marian Macsai, MD chief medical officer, Oyster Point Pharma.
Two of the four scientific analyses will be featured paper presentations, including analyses comparing the levels of inflammatory cytokines in the tear film in relation to the presenting signs and symptoms scores in patients with and without dry eye disease. A second paper presentation will feature a post-hoc analysis from clinical trials of OC-01 (varenicline solution) nasal spray analyzing its efficacy in patients with and without antidepressant/anti-anxiety agent use.
“It is important to identify the underlying causes of tear film disruption in dry eye disease in order to target treatment efforts,” Francis Mah, MD, said in a company news release. “We studied the amount of basal tear film and its impact on inflammatory cytokines in healthy and dry eye disease patients to evaluate the possible influence of increased basal tear production on tear cytokine concentrations. We are excited to share the results of our study at World Cornea Congress.”
"Antidepressants and anti-anxiety agents can have anticholinergic side effects that may reduce tear production.1-4 As such, we analyzed the efficacy of Tyrvaya for the treatment of dry eye disease in patients with and without systemic antidepressant/anti-anxiety agent use,” said Christopher E. Starr, MD, FACS. “I am encouraged by the results of our research and look forward to presenting this featured paper presentation at World Cornea Congress.”
The Following are Details for Featured Paper Presentations:
Title: Pro and Anti-Inflammatory Cytokine Levels in Tears of Dry Eye Subjects
Authors: Francis Mah, MD; Marian Macsai, MD; Puja Shah, OD; Laura Hendrix, MS; Eric Carlson, PhD
Date/Time: Wednesday, September 28, 4:00 – 5:30 PM CDT
Title: Efficacy of OC-01 (varenicline solution) 0.03mg for Treatment of Dry Eye Disease Signs and Symptoms in Subjects with and without Antidepressant/Anxiolytic Use: Post-hoc Analysis of ONSET-1 and ONSET-2 Clinical Trials
Authors: Christopher Starr, MD, FACS; Andrea Gibson, PhD; Gretchen Blemker, OD; Laura Hendrix, MS
Date/Time: Thursday, September 29, 10:30 AM – 12:00 PM CDT
The Following are Details for Poster Presentations via Electronic Portal:
Title: Efficacy of OC-01 (varenicline solution) 0.03 mg for Treatment of Dry Eye Disease Signs and Symptoms in Subjects with and without Systemic Anticholinergic Use: Post-hoc Analysis of ONSET-1 and ONSET-2 Clinical Trials
Authors: Brent Kramer MD, Terry Kim MD, Laura Hendrix MS, Marian Macsai MD, and Andrea Gibson PhD
Title: Evaluation of OC-01 (varenicline solution) Nasal Spray 0.03 mg Efficacy Based on Menopausal Status: Post-hoc Analysis of ONSET-1 and ONSET-2 Clinical Trials
Authors: Lisa Nijm, MD, JD; Andrea Gibson, PhD; Gretchen Blemker, OD; Laura Hendrix, MS