New Study Unveils How Immune Cells Defend the Eye Against Inflammation

In a new study, researchers led by Sue Menko, PhD, of Thomas Jefferson University, have revealed how immune cells play a critical role in resolving inflammation on the surface of the eye’s lens. Published in The American Journal of Pathology, the research builds on Dr. Menko's earlier findings that immune cells are recruited to the lens surface during acute injury and prolonged inflammation elsewhere in the eye, according to an article posted on the Thomas Jefferson University website. 

Dr. Menko’s team discovered that specific immune cells—macrophages with an immunoregulatory phenotype and regulatory T cells (Tregs)—are actively drawn to the lens surface during periods of inflammation. These immune cells work together to restore balance and reduce inflammation. Notably, these cells stay on the lens surface until the inflammation is resolved.

"Debunking the thought that the eye could not care for itself is a big deal," said Dr. Menko. "This helps us understand disease processes like uveitis and how they’re resolved in the eye. Maintaining a non-inflammatory condition in the eye is crucial to preserve vision, and we now know that the eye has inherent mechanisms to do that.”

Read the full article here.