Maculopathy Tied to Pentosan Polysulfate Sodium May Worsen After Drug Cessation
07/24/2020
Pentosan polysulfate sodium (PPS)-associated maculopathy may continue for at least 10 years after drug cessation and in some cases may pose a threat to central vision, according to a case report, Reuters reported.
The condition “is a recent clinical finding suggestive of a toxic effect associated with long-term use of the medication,” Dr. Rachel Shah of Emory University School of Medicine in Atlanta told Reuters Health by email. “In our study, all patients experienced subtle but continued evolution of the disease process even after discontinuation of the medicine, suggesting that the toxic effects persist, and in some cases, significantly worsen after the medicine is stopped.”