Long-Term Pentosan Polysulfate Sodium Use Tied to Macular Disease

Use of the interstitial cystitis drug pentosan polysulfate sodium (PPS) was associated with a new diagnosis of macular disease at the 7-year follow-up in a large retrospective matched cohort study, according to a Reuters report.

“This study adds to a growing body of literature linking PPS exposure with a vision-threatening retinal disorder,” Dr. Nieraj Jain of Emory Eye Center in Atlanta told Reuters Health by email. “In contrast to the recent case series (http://bit.ly/2ZWMiVA), this study evaluated de-identified records for millions of patients nationwide.”

“Our findings confirm that this is a large-scale public safety issue,” he said.

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