Aviceda Announces 3 Presentations on AVD-104, its Lead Glyco-mimetic Nanoparticle, As Treatment for GA at ARVO

Aviceda Therapeutics announced its upcoming oral and poster presentations at the 2023 Association for Research in Vision and Ophthalmology (ARVO) annual meeting in New Orleans, April 23-27, 2023. Detailed results from each of these three studies will be reported at the conference.

“We are excited to present our data at ARVO this year. We are committed to developing breakthrough therapeutics, beginning with our lead ophthalmic asset, AVD-104, for geographic atrophy (GA) secondary to age-related macular degeneration (AMD), and will demonstrate the potential of glyco-immunology to lead to the first treatment that truly addresses the underlying pathobiology of this devastating blinding disease by attacking activated macrophages and microglia, while also inhibiting complement activation. We look forward to sharing our results with the retina community as we quickly work to bring AVD-104 to our patients with our impending first-in-human clinical trials,” Tarek S. Hassan, MD, Chief Development Officer of Aviceda, said in a company news release. 

“AVD-104 targets the direct cause of GA due to AMD, activated macrophages that phagocytose retinal cells. Blocking complement alone removes a stimulus for these cells which slows down but does not stop this cellular process. AVD-104 directly stops activated macrophages, while also inhibiting the complement pathway, akin to letting the foot off the gas pedal while applying the brakes at the same time. The dual mechanism of action of AVD-104 has the potential to dramatically inhibit or stop the growth of GA completely in patients with AMD,” said Michael Tolentino, MD, Chief Technology Officer of Aviceda.

Oral Presentation Details:

Modulation of Macrophages and Complement Dysfunction in Nonexudative Age-Related Macular Degeneration Utilizing a Sialic-acid Coated Nanoparticle, Baruch Kuppermann, MD, PhD.

Scientific Poster Details:

Targeting Self-Recognition Pattern Receptors on Retina Immune Cells with an Engineered Glycan-coated Nanoparticle as a Novel Therapy for Nonexudative AMD, Diyan Patel, MS.

Modulation of Retinal Inflammatory Macrophages by Sialic-Acid Coated Nanoparticles as Novel mechanism for Nonexudative AMD Treatment, Anitha Krishnan, PhD.