Alcon Reinforces Strength of Ophthalmology Portfolio With Surgical Device Scientific Presence at ASCRS

Alcon will present a breadth of data during the American Society of Cataract and Refractive Surgery (ASCRS) 2021 annual meeting, taking place July 23-27 in Las Vegas. More than 60 abstracts featuring Alcon ophthalmic products and equipment will be presented. The full abstract book, registration links for events taking place onsite and booth information is available at MyAlconatASCRS.com.

“We are thrilled to be back in person at a large-scale meeting with our ophthalmology community for the first time since 2019,” Sergio Duplan, President, North America at Alcon, said in a company news release. “Alcon once again has a significant presence at ASCRS, highlighting our ongoing commitment to scientific and technological advancements as we continue to pave the path forward in ophthalmic surgical innovation.”

Of the abstracts to be presented, more than half will focus on Alcon’s market-leading presbyopia-correcting intraocular lens technologies, including AcrySof Vivity IQ IOL, AcrySof PanOptix IOL as well as the novel Clareon IOL. The optical designs and material of these IOLs provide patients a variety of options to See Brilliantly, reinforcing Alcon’s commitment to innovation in this space.

Reduced Spectacle Dependence and High Patient Satisfaction with Vivity IOL, the first and only non-diffractive extended depth of focus (EDOF) IOL in the U.S.¹⁰

Key data continues to demonstrate that Vivity delivers an extended range of vision while maintaining a monofocal-like visual disturbance profile.^1-4,10 Study findings are based on real-world, patient-reported outcomes for those implanted with the Vivity lens.^1-4 The data affirms the results from a Vivity U.S. clinical trial, which demonstrated:

• 94% and 92% of Vivity patients reported very good or good vision at distance and arm’s length, respectively, without glasses in bright light, with vision of 20/20 at distance, greater than 20/25 at intermediate and functional near (20/32).^10,11*†
• 90% of patients implanted with Vivity™ were satisfied with their results and would get the lens again.^11*‡

Presentations will also showcase additional Vivity results and key findings, including:

• The Revive Study: Long Term Outcomes of a Novel Non-Diffractive Extended Vision IOL Versus Monofocal Control IOL, Presented by Dr. Brian M. Shafer (July 25, 1:55-2:00 PM).
• Visual Outcomes and Quality of Vision after Implantation of a New Presbyopia-Correcting Intraocular Lens with a Non-Diffractive Design, Presented by, Dr. Cathleen McCabe (July 25, 9:10-9:15 AM).
• Visual Performance of Non-Diffractive Extended Depth of Focus and Neutral Aspheric Monofocal Intraocular Lens, Presented by Dr. Seth Pantanelli (July 25, 10:00-10:05 AM).

PanOptixTrifocal IOL Provides Excellent Continuous Vision.^12,13 PanOptix is the first and only trifocal IOL in the U.S. and is the most implanted trifocal IOL in the world.

With PanOptix, 20/20 near, intermediate, and distance vision is now possible.^13±° A meta-analysis of U.S. and worldwide data reinforces that PanOptix IOL provides patients continuous 20/25 or better vision from distance to near (33cm/13in);¹² additional key presentations include:

• A Prospective Randomized Comparison of Bilaterally Implanted Extended Depth of Focus and Trifocal Intraocular Lenses, Presented by Dr. Satish S. Modi (July 26, 10:05-10:10 AM).
• A Cost-Benefit Analysis Comparing Trifocal Intraocular Lens (IOL) with Monofocal IOL from Patient Perspective in the USA, Presented by Dr. John P. Berdahl (July 26, 10:55-11:00 AM).
• Evaluation of Quality of Vision and Spectacle Independence with Bilateral Implantation of a New Trifocal Intraocular Lens, Presented by Dr. Andrew C. Shatz (July 24, 8:00-8:05 AM).

ARGOS Biometer Delivers Substantial Time Efficiencies to Cataract Surgery Practices, Surgeons and Patients, as the industry-leading Swept Source Optical Coherence Tomography (SS-OCT) biometer equipped with image guidance for a faster and smarter planning solution.^14-18

At Alcon, we know that connectivity matters, and data being presented at ASCRS highlights that ARGOS delivers substantial time efficiencies for cataract surgery practices, surgeons, and patients through its superior acquisition rate and integration functionality.⁹ This time-efficiency model showed that for every 1,000 patients receiving a toric IOL, integrating ARGOS with image guidance can save 58 hours and 51 minutes versus LENSTAR alone.⁹ Additional studies on ARGOS will be presented, including:

• Comparing the Toric Calculations with the Keratometric Readings from a Swept-source OCT Biometer Versus a Scheimpflug Topographer, Presented by Dr. H. John Shammas (July 25, 4:00-4:05 PM).
• Targeted Literature Review of the Current Burden and Outcomes of Cataract Surgery with and without Image Guided Systems, Presented by Dr. Sam Multack (July 23, 7:00-8:00 PM).

NGENUITY 3D Visualization System Heads-Up Display Brings Ergonomics to Surgical Experience; leading 3D visualization system provides precision, depth and detail during cataract and vitreoretinal surgery.¹⁹

In a new assessment of musculoskeletal (MSK) complaints, more than 80% of ophthalmologists reported exacerbated MSK pain from the postural position required when examining patients and performing surgery with traditional binocular microscopes – up from 50-70% reported in prior studies.²⁰ A different study found that the postural musculature was less activated with the NGENUITY 3D Heads-up Display (HUD) than with Traditional Microscope (TOM) in Ophthalmic Surgery. Alcon will present these studies along with other key data at the meeting to further explore the benefits of implementing the NGENUITY 3D HUD in Surgical practices:²¹

• Prospective Randomized Evaluation and Comparison of the Effect of Decreased Illumination on Visual Recovery Following Cataract Surgery, Presented by Dr. Eric D. Rosenberg (July 26, 10:47-10:52 AM).

Other studies of note will be presented at the meeting including, but not limited to:

• Clinical and Refractive Outcomes after Topography-Guided Refractive Surgery Planned Using Phorcides Analytic Surgery Planning Software, Presented by Dr. Mark C. Lobanoff (July 25, 8:05-8:10 AM).
• In-Vitro Comparative Analysis of the Cavitation and Particle Image Velocimetry Characteristics of Two Phacoemulsification Tips, Presented by Dr. Jamie Zacharias (July 24, 8:40-8:45 AM).
• Comparison Between Systane iLux and Lipiflow in the Treatment of Meibomian Gland Dysfunction (MGD): A 12-Month, Multicenter Study, Presented by Dr. Joseph Tauber (July 24, 2:37-2:42 PM).

Alcon will be bringing connectivity to life during ASCRS with a series of interactive activities. Watch this space as the company continues to innovate in digital health. Follow along on Alcon social channels and join the conversation at #ConnectBrilliantly. Visit the Alcon booth (#3601) during the meeting to learn more about our surgical products and services, as well as our dry eye devices portfolio, which helps doctors see and restore the ocular surface health of their patients. For information on Alcon events, activations and abstracts, please visit MyAlconatASCRS.com.

References

1. Allen, Quentin B., MD. Site Level Data from a Multicenter Study of Patient Profiles, Satisfaction, and Visual Range of a Novel Non-Diffractive Extended Vision IOL. ASCRS, Las Vegas, NV. 25 July 2021.
2. Hovanesian, John A., MD. Evaluation of a Non-Diffractive Multifocal IOL (Vivity) for Glare/Haloes, Spectacle Independence, and Patient Satisfaction. ASCRS, Las Vegas, NV. 25 July 2021.
3. Shafer, Brian M., MD. The Revive Study: Long Term Outcomes of a Novel Non-Diffractive Extended Vision IOL Versus Monofocal Control IOL. ASCRS, Las Vegas, NV. 25 July 2021.
4. Shafer, Brian M., MD. One Year, Site-Level Outcomes of a Novel Non-Diffractive Extended Vision Intraocular Lens Versus Control. ASCRS, Las Vegas, NV. 25 July 2021.
5. Blehm, Clayton G., MD. Evaluating Visual Acuity and Spectacle Independence After Bilateral Implantation of a Trifocal Intraocular Lens. ASCRS, Las Vegas, NV. 24 July 2021.
6. Chang, John So-Min, MD. Early Clinical Outcome of a Trifocal Intraocular Lens in Asian Eyes. ASCRS, Las Vegas, NV. 23 July 2021.
7. Greenwood, Michael D., MD. Outcomes and Patient Satisfaction of a Trifocal IOL in Post-Refractive Patients. ASCRS, Las Vegas, NV. 24 July 2021.
8. Mueller, Brett H. II, DO, PhD. Prospective Analysis to Assess Placing a Panoptix Trifocal LENS in Patients Who Have HAD Myopic Laser Vision Correction Surgery. ASCRS, Las Vegas, NV. 26 July 2021.
9. Woodard, Lawrence, MD. Time Efficiency of an Innovative Optical Biometer in Cataract Surgery: A Time-and-Motion Study. ASCRS. Las Vegas, NV. 23 July 2021.
10. AcrySof® IQ Vivity™ Extended Vision IOL DFU. Alcon Laboratories, Inc.; 2020.
11. Alcon Data on File. 2019.
12. Maxwell, Andrew W., MD, PhD. Post-operative Visual Outcomes with a Diffractive Trifocal Intraocular Lens: A Meta-analysis of USA and Worldwide patients. ASCRS, Las Vegas, NV. 26 July 2021.
13. AcrySof® IQ PanOptix DFU. Alcon Laboratories, Inc.; 2019
14. Tamaoki A, Kojima T, Hasegawa A, et al. Clinical Evaluation of a New Swept-source Optical Coherence Biometer That Uses Individual Refractive Indices to Measure Axial Length Cataract Patients. Ophthalmic Res. 2019;19;1-13.
15. Shammas HJ, Ortiz S, Shammas MC, Kim SH, Chong C. Biometry Measurements Using a New Large Coherence-Length Swept-Source Optical Coherence Tomographer. J Cataract Refract Surg. 2016; 42:50-61.
16. Hussaindeen JR, Mariam EG, Arunachalam S, et al. Comparison of Axial Length Using a New Swept-Source Optical Coherence Tomography-Based Biometer. PLOS One. December 2018.
17. Zeiss IOL Master 700 510k Submission 2015.
18. Whang, Woong-Joo. Predictive Accuracy of Partial Coherence Interferometry and Swept-source Optical Coherence Tomography For Intraocular Lens Power Calculation. Scientific Report. September 2018.
19. Alcon Data on File. 2016.
20. Tan, Nicholas E., Assessment of Musculoskeletal Complaints among Ophthalmologists. ASCRS, Las Vegas, NC. 26 July 2021.
21. Hura, Arjan, MD. Intraoperative Electromyogram Analysis of Postural Musculature with 3D Heads-up Display vs. Traditional Microscope in Ophthalmic Surgery. ASCRS, Las Vegas, NV. 26 July 2021.

*Results from a prospective, randomized, parallel group, subject- and assessor-masked, multisite trial of 107 subjects bilaterally implanted with the AcrySof® IQ Vivity™ IOL and 113 with the AcrySof® IQ IOL with 6 months’ follow-up. Patient-reported outcomes for spectacle independence were evaluated subjectively through IOLSAT questionnaire.

‡In response to the question asked 6 months after surgery: “Given your vision today, if you had to do it all over, would you have the same lens implanted again?”

†Patients were asked, “How well did you see without wearing eyeglasses in the past 7 days?” Patients who reported not using glasses at least some of the time were asked to rate their quality of vision.

^±Based on mean value of binocular defocus curve at near, intermediate, and distance at 6 months (n=127).

°Snellen VA was converted from logMAR VA. A Snellen notation of 20/20^-2 or better indicates a logMAR VA of 0.04 or better, which means 3 or more of the 5 ETDRS chart letters in the line were identified correctly.