Course of Stargardt Disease Varies Between Siblings

Disease course is frequently discordant between siblings with Stargardt disease (STGD1) who carry the same ABCA4 gene variant, new findings show, according to a Reuters report.

“This study shows that there are other factors that determine the course of a genetic disease, and we do not know what these are,” Dr. Carel B. Hoyng of Radboud University Medical Center in Nijmegen, the Netherlands, the study’s senior author, told Reuters Health by phone.

STGD1 is an autosomal recessive retinal dystrophy, with visual symptoms that usually emerge in childhood or early adolescence.

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