A new study on serum drops for dry eye treatment.

A study published in the British Journal of Ophthalmology examined the efficacy of using allogeneic cord blood serum drops and allogeneic peripheral blood serum drops for the treatment of severe dry eye.

Let's take 10 seconds to differentiate autologous, allogeneic, and cord blood.

Autologous serum drops use serum taken from a patient’s own blood, unlike allogeneic serum drops, which are from a donor’s blood. Cord blood, on the other hand, is collected from placenta umbilical veins at birth.

Why might you want allogeneic serum rather than autologous serum?

Not all patients are good candidates as donors due to underlying systemic inflammatory diseases, age, and other comorbidities.

Why is putting serum in the eye helpful?

Serum contains growth factors, cytokines, vitamins, and nutrients that are critical to maintaining homeostasis of the ocular surface.

Let's get back to the study.

A total of 60 patients with severe dry eye were included in the study. Half of them were treated with cord blood serum drops, while the other half was treated with peripheral serum blood drops. Both groups used the drops eight times a day for 1 month. The researchers assessed both subjective (OSDI questionnaire, etc.) and objective (TBUT, corneal staining, Schirmer testing, etc.) measures of dryness.

What did they find?

Corneal staining was more significantly reduced after treatment with cord blood serum. OSDI score reduction was observed in both groups, but the cord blood group reported significantly less grittiness and pain.

The take home.

This study supports the use of allogeneic peripheral blood eye drops from adult donors as a safe blood product effective in decreasing epithelial corneal damage.


Can you diagnose a concussion by looking at the eyes?

According to a new study it’s possible—by measuring quantitative pupillometry.

What is quantitative pupillometry?

It's an objective way to measure cognitive changes by looking at a patients' pupils. Video recordings are taken to analyze a patient's pupil size and their response to light. Changes in pupil response (i.e., how brisk a pupil responds) have been linked to brain injuries.

Why are we talking about this?

Because this study was just published in the Journal of Neurosurgery, and shows a measurable change in pupil response after a head injury.

Are there devices out there that can do this?

Yes, there is an app and a handheld device. This study used the hand held device. (via)


Looking for a good retinal photo?

This new website can help. Retina Rocks has a huge database of retinal photos, complete with diagnoses for learning or teaching. As an added bonus—it's free!

Dental exams > eye exams.

In a new survey of more than 4,000 parents, 57% of respondents ranked eye exams as less important than dentist and pediatrician visits. (via)



See you next week!